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Janumet 50/500mg Tablet 15 Tablet(s) in Strip
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Janumet 50/500mg Tablet 15 Tablet(s) in Strip

Original price was: ₹386.00.Current price is: ₹270.00.

Categories: ,
Uses Type 2 Diabetes mellitus

Therapy

 Anti-diabetic

Side effects

 Nausea, runny nose, headache, sore throat, flatulence

Salt Content

 Metformin Hydrochloride(500.0 Mg)+Sitagliptin(50.0 Mg)

Janumet 50/500mg Tablet is used alongside diet and exercise to control blood sugar in adults with type 2 diabetes when a single medicine is not enough. It contains sitagliptin and metformin, which lower glucose through two separate mechanisms.

Metformin reduces the glucose the liver releases and improves how well muscle responds to insulin. Sitagliptin blocks the enzyme DPP-4, protecting the gut hormones that prompt the pancreas to release insulin after a meal and reduce glucagon, so insulin is released only when glucose is actually rising.

Take it twice daily with or immediately after food, which substantially reduces the nausea, metallic taste and loose stools metformin can cause. Do not stop when your readings improve; that improvement is the treatment working.

Seek urgent medical attention for severe persistent upper abdominal pain spreading to the back, which may indicate pancreatitis, or for unusual muscle pain, rapid breathing and extreme tiredness, which may indicate the rare complication lactic acidosis.

Kidney function must be checked before starting and at least yearly, and the medicine stopped before contrast scans and surgery. Long-term metformin lowers vitamin B12, so levels should be monitored periodically.

Istamet 50/500mg tablet, Sitazor 50/500mg tablet and Glura M 500mg tablet are a few more tablets that also contain sitagliptin and metformin.

Uses

Janumet tablet is used to control high blood sugar in patients having type 2 diabetes mellitus, along with a healthy diet and regular exercise.

Contraindications

  • If you are allergic to sitagliptin, metformin or any other ingredients of Janumet tablet.
  • If you have severe kidney or liver disease.
  • If your diabetes is not under control and you also have high blood sugar, nausea, vomiting, loose motions, rapid loss of weight, pain in the stomach, breathing difficulty, sleepiness, etc.
  • If you have dehydration or you have the presence of severe infection.
  • If you have to go to do an x-ray or scan dye is injected in your blood before doing the x-ray or scan.
  • If you have a recent history of a heart attack.
  • If you are a heavy alcohol drinker.
  • If you are a lactating mother.

Side effects

  • Nausea
  • Vomiting
  • Stomach pain
  • Diarrhoea
  • Constipation
  • Flatulence (gas)
  • Low blood sugar

Precautions and Warnings

Pregnancy

Pregnancy

Can I take Janumet 50mg/500mg tablet during pregnancy?

Unsafe

50mg/500mg tablet should not be taken while pregnant. If a patient wishes to become pregnant or if a pregnancy occurs, treatment should be stopped immediately.

Breast Feeding

Breast Feeding

Can I take Janumet 50mg/500mg tablet while breastfeeding?

Unsafe

Driving

Driving

Can I drive if I have consumed Janumet 50 mg/500 mg tablet?

With Caution

Alcohol

Alcohol

Can I consume alcohol with Janumet 50 mg/500 mg tablet?

With Caution

Other General Warnings

Other General Warnings

Talk to your doctor if
  • You have a skin blister after taking this medicine.
  • You have a fever, vomiting, loose motion, heat exposure, and less fluid intake.
  • You have vomiting, pain in the stomach, breathing difficulty, tiredness, muscle cramps, decreased body temperature, and decreased heartbeat after taking this medicine.
  • You have low blood sugar after taking other anti-diabetic medicines along with this medicine.
  • You have type 1 diabetes mellitus.
  • You are undergoing any surgery.
  • Your doctor tells you that you have increased triglyceride levels in your blood and you have gallstones.

Directions for Use

  • Janumet tablet should be taken as directed by your doctor.
  • Swallow it as a whole with a glass of water, do not cut, break or chew the medicine.
  • It should be taken with meals.
  • For optimal results, it would be best to take it at a fixed time and not consume it more than that prescribed by your doctor.
  • Do not stop taking Janumet 50mg/500mg tablet on your own without informing your doctor.

Storage and disposal

  • Store Janumet tablets at a temperature not above 30°C in a cool and dry place.
  • Keep it out of the reach of children and pets.

Quick Tips

  • Along with taking Janumet tablet, it is essential that you do certain lifestyle modifications like exercising for 30 minutes daily, maintaining a healthy weight, managing stress, avoiding smoking, and drinking alcohol.
  • It is also advised to have a balanced diet with adequate fruits and vegetables to control blood sugar levels effectively.
  • Regularly monitor your blood sugar levels as directed by your doctor and report any changes.
  • It is essential to take this tablet at the same time every day and not to skip doses. If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and take your next dose at the regular time.
  • Some individuals may experience headache, stomach pain, diarrhoea, and nausea/vomiting after taking the Janumet 50/500mg tablet. Inform your doctor if these effects bother you or do not go away.
  • Talk to your doctor if you have kidney or liver disease.
  • Take Janumet with your meals for better digestion. Do not cut or break the tablets; swallow them whole. If you have trouble, talk to your doctor.

Dosage

Overdose

Symptoms of overdose include severe nausea or vomiting, pain in the stomach, muscle cramps, rapid breathing. If you have taken too much of this medicine then contact your doctor or reach out to the nearest hospital immediately.

Missed a Dose

If you have missed taking any dose of this medicine then take it as soon as you remember. If it’s already time for the next dose then skip the missed dose and follow the regular dosing schedule.

How does this medicine work?

Sitagliptin works by increasing insulin production by the body after a meal and decreasing sugar production by the body. Metformin works by restoring the natural response of the body to insulin and decreasing sugar production by the body.

Interactions

Interactions with other medicines

  • Some medicines can affect how Janumet tablet works, or this medicine itself can reduce the effectiveness of other medicines simultaneously.
  • Tell your doctor about all the medicines, supplements, or herbs you are taking to avoid any possible interaction.
  • Especially if you are taking other antidiabetic medicines.

Interactions with food items

Janumet tablet should be taken with food to avoid stomach upset if taken on an empty stomach. There are no known food or beverage interactions known with Janumet 50mg/500mg Tablet.

Frequently Asked Questions (FAQs)

What is the use of Janumet 50/500mg Tablet?

Janumet 50/500mg Tablet is used to control blood sugar in adults with type 2 diabetes. It is prescribed alongside diet and exercise when one medicine alone is not keeping glucose in the target range, and it combines two treatments that lower blood sugar in different ways.

Why does Janumet 50/500mg Tablet contain two medicines?

Metformin reduces the amount of glucose the liver releases and helps your muscles use insulin better. Sitagliptin works on a separate pathway, protecting the gut hormones that tell the pancreas to release insulin after eating. Because they act on different problems, the two together lower blood sugar more than either alone.

Does Janumet 50/500mg Tablet cause low blood sugar?

On its own it rarely does, because sitagliptin only stimulates insulin when glucose is actually rising and metformin does not force insulin release at all. The risk becomes real if you also take a sulfonylurea such as glimepiride, or insulin, in which case those doses often need reducing.

Why must I take Janumet 50/500mg Tablet with food?

The metformin component commonly causes nausea, a metallic taste, loose stools and abdominal discomfort, and taking the tablet with or immediately after a meal reduces this considerably. Starting at a low dose and building up slowly also helps your gut adjust.

What is lactic acidosis and how worried should I be?

It is a rare but serious build-up of acid in the blood associated with metformin, occurring mainly when the kidneys cannot clear the drug. Warning signs are unusual muscle pain, deep or rapid breathing, severe tiredness, stomach pain with vomiting, and feeling very cold. Seek emergency care if these appear. Risk rises with dehydration, severe illness, heavy alcohol use and kidney impairment.

Do I need to stop Janumet 50/500mg Tablet before a scan or surgery?

Yes, usually. Metformin must be stopped before any scan using iodinated contrast dye and before surgery under general anaesthesia, because a temporary drop in kidney function can allow it to accumulate. Your doctor will tell you when to stop and when it is safe to restart, normally at least 48 hours afterwards.

Can Janumet 50/500mg Tablet cause vitamin B12 deficiency?

Long-term metformin reduces absorption of vitamin B12, and the resulting deficiency can cause tiredness, tingling and numbness in the hands and feet. This is often mistaken for diabetic nerve damage. Your doctor should check your B12 level periodically, particularly if you have been on treatment for several years.

What is pancreatitis and what should I watch for?

Inflammation of the pancreas has been reported with sitagliptin and similar medicines. The warning sign is severe, persistent pain in the upper abdomen that may spread through to the back, often with vomiting. Stop the medicine and seek urgent medical attention if this occurs.

How will my kidneys affect this treatment?

Kidney function determines whether you can take metformin at all. Your doctor will check it before starting and at least once a year, more often if it is already reduced. The dose is lowered when function declines, and the medicine is stopped altogether when it falls below a defined level.

Can I drink alcohol with Janumet 50/500mg Tablet?

Heavy or binge drinking should be avoided entirely. Alcohol increases the risk of lactic acidosis with metformin and can cause unpredictable low blood sugar, particularly if you drink without eating. If your doctor permits alcohol, keep it modest and always take it with food.

What should I tell my doctor before starting Janumet 50/500mg Tablet?

Mention kidney or liver disease, heart failure, a history of pancreatitis, gallstones, alcohol dependence, and any planned scan or surgery. Tell your doctor if you are pregnant, planning pregnancy or breastfeeding, and list all other medicines including diuretics and painkillers.

What happens if I miss a dose of Janumet 50/500mg Tablet?

Take it as soon as you remember with food, unless your next dose is nearly due, in which case skip it. Never take two doses together, as this sharply increases the risk of stomach upset. Tell your doctor if you frequently forget.

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