• Dolo 650 is primarily used as an effective fever reducer for adults and children above 12 years.
• It also provides quick relief from migraines and headaches (stress-related and tension).
• In a few cases, Dolo 650 is used to treat body aches, fever, and general discomfort caused by cold and flu.
• Some doctors prescribe it to treat toothaches, minor joint discomfort, mild to moderate back pain, and soreness after immunisations.
• Dolo 650 also helps in managing period-related cramps and discomfort.
• Dolo 650 can be used for ear pain relief. However, it only treats the symptom of pain, not the underlying cause of the earache.

• It is advised not to use Dolo 650 if you have an allergy or hypersensitivity to paracetamol or any of its components.
• If you are suffering from severe kidney disease, active liver disease, liver failure, or chronic or severe malnutrition.
• Use with caution and ask a doctor first if you are dehydrated.

• Nausea or stomach discomfort
• Loss of appetite
• Mild skin rash
• Dizziness (rare)

• Severe allergic reactions – Difficulty breathing, swelling of the face or throat
• Unusual bleeding or bruising
• Persistent nausea or vomiting
• Dark urine or pale stools
• Severe stomach pain
• Yellowing of skin or eyes (jaundice)

• Stevens-Johnson syndrome
• Acute generalised exanthematous pustulosis
• Toxic epidermal necrolysis

Other General Warnings

• You have a history of liver disease, kidney disease, or heart disease.
• You have high blood pressure.
• You are taking any other medications or products that contain paracetamol.
• You are consuming too much alcohol or consuming alcohol regularly.
• You are suffering from chronic malnutrition.

• For adults and children above 12 years, the recommended dosage of Dolo 650 mg is one tablet every 4 to 6 hours as required for relief from fever or pain.
• The maximum limit is 4 tablets in 24 hours, and it is essential to maintain a minimum gap of 4 hours between doses.
• Dolo 650 mg tablet should be taken with a full glass of water.
• You can take it with or without food, but taking it after meals may help prevent stomach discomfort.
• Always swallow the tablet whole; do not crush, chew, or break it.
• Avoid overuse of the recommended dose, as an overdose can cause liver damage.
• Stop taking Dolo 650 mg once your fever or pain reduces, as unnecessary use may harm the liver.
• If symptoms persist for more than 3 days, consult a doctor instead of self-medicating.
• Always keep track of other medicines you are taking, since many cold and flu tablets already contain paracetamol. Combining them with Dolo 650 mg can cause an overdose.
• For safe and effective use, always take Dolo 650 mg only in the recommended dose and duration as prescribed by your doctor.

• Dolo 650 tablets should be stored at room temperature, not exceeding 25 °C (77°F).
• Keep in original packaging away from light and moisture.
• Store in a dry place away from the bathroom and kitchen.
• Keep it out of the reach of children and pets.
• Do not flush unused Dolo 650 mg tablets into toilets or sinks.
• Remove or black out all personal information from packaging and dispose of it.

• Wait at least 4 to 6 hours between doses. To stay safe, do not take more than four tablets in a 24-hour period without consulting your doctor first.
• For fever, do not use for more than 3 days. For pain, limit use to 5 days. If your symptoms don’t improve, you must see a healthcare provider.
• Dolo 650 mg tablet is not recommended for children under 12 years of age. Always consult a doctor for pain or fever relief in younger children. Use only a doctor-recommended paediatric paracetamol formulation and dose based on the child’s weight.
• While generally considered safe, you must consult your doctor before using Dolo 650 during pregnancy or while breastfeeding to ensure the safety of you and your baby.
• Inform your doctor about all medications you take, especially blood thinners or other pain relievers. Taking Dolo 650 mg tablets with antibiotics is generally safe, but it’s always best to consult a doctor for confirmation.
• Avoid long-term use of the Dolo 650 mg tablet unless prescribed. It can lead to serious side effects like stomach bleeding or kidney problems. Regular medical check-ups are necessary for extended use.
• A diabetic patient can usually take Dolo 650 (paracetamol) for pain or fever, but dosage caution is important, especially if there are liver or kidney problems or other medicines are being used, so consult your doctor before taking it.

Overdose

Missed a Dose

• Dolo 650 mg tablet works through a dual mechanism. For pain, it works by blocking the brain’s pain signals and reducing the production of chemicals (prostaglandins) that cause pain and inflammation.
• To lower a fever, it acts on the hypothalamus, the part of your brain that functions as the body’s thermostat. This helps reset your internal temperature to a normal level, efficiently bringing down the fever by promoting heat loss through sweating.
• After taking a Dolo 650 tablet, you can expect to feel relief relatively quickly, as it begins to work within 30 to 60 minutes. The tablet reaches its maximum effectiveness, providing peak relief from pain and fever, between one and three hours after consumption.
• The effects of a single dose are designed to last for a duration of four to six hours, helping you stay comfortable before another dose may be necessary.

Interactions with other drugs