• If you are allergic to metformin, glimepiride or any other ingredients of Zoryl M2 forte.
• If you are pregnant or are breastfeeding.
• If you have serious kidney failure or liver failure.
• If you have any metabolic acidosis (too much acid in the body fluids) like lactic acidosis, diabetic ketoacidosis or diabetic pre-coma.
• If you have dehydration, severe infections, shock and injections containing iodine.
• If you have had heart or lung failure, the recent incidence of heart attack and shock.
• If you are an alcoholic.

• Headache
• Nausea
• Vomiting
• Nausea
• Sleepiness
• Low blood sugar level

Other General Warnings

• You experience extreme hunger, headache, nausea, vomiting, sleepiness, restlessness, aggression, reduced alertness, confusion, shakiness or dizziness. These could be signs of low blood sugar. If you have any of these, immediately have sugar or sweet juice. Inform your doctor as you may need a change in your medicine’s dose.
• You are experiencing pins-and-needles sensation, numbness and weakness.
• You are going to have a diagnostic imaging test that involves an injection of iodine.
• You have dehydration due to diarrhoea, vomiting or limited fluid intake.
• You have suffered through trauma.
• You have to undergo surgery in the near future.
• You have serious kidney and liver problems.
• You have a thyroid disorder.
• You are overweight (specific diet restriction may be suggested).

• Store it at room temperature in a dry place.
• Protect it from moisture.
• Keep it out of the reach of children and pets.
• If the medicine has passed its expiry date, please dispose of the medicine appropriately.

Overdose

• An overdose of this medicine may lead to severe hypoglycaemia and lactic acidosis (excessive lactic acid build-up) & (low blood sugar).
• This can result in a headache, nausea, vomiting, sleep disturbances, restlessness, impaired alertness and reactions, mood disorders, confusion, dizziness, etc.
• If you experience these, immediately take glucose or juice or sugar-containing products (sugar candy).
• Contact your doctor immediately or visit the nearest hospital as you may require close monitoring for the next few hours.

Missed a Dose

• A missed dose may lead to high blood sugar levels, which includes symptoms like feeling thirsty, excessive urination, loss of appetite, drowsiness, a fruity smell from breath, etc.
• If you have missed any dose of this medicine, take it as soon as you remember.
• If it’s time for your next dose, then skip the missed dose and continue with your regular dosing schedule.
• Do not take a double dose of this medicine to compensate for the missed one.

• This combination is known to control blood sugar to a greater extent than metformin or glimepiride alone. Glimepiride lowers the blood sugar level by increasing the release of insulin hormone from the pancreas.
• Insulin moves sugar (glucose) from the blood into the cells.
• Metformin decreases the absorption in the intestine and production of sugar by the liver.
• Both of these components are known to increase the insulin sensitivity of the body (which allows the cells of the body to use blood glucose more effectively, reducing blood sugar).

Interactions with other medicines

• You may have symptoms of low blood sugar if you are taking other medicines for diabetes like Insulin, Pioglitazone, medicines for high blood pressure (ACE inhibitors like Captopril), Steroids, Chloramphenicol, Fenfluramine, Fenyramidol, medicines to lower blood cholesterol (fibrates), medicines to treat mood (Fluoxetine), medicines to treat blood clotting like Coumarins, Cyclophosphamide, Miconazole, Probenecid, antibiotics like Clarithromycin, Doxycycline, Ofloxacin, etc.
• You may have symptoms of high blood sugar if you are taking oral contraceptives, Acetazolamide, water pills, Phenytoid, Rifampicin, medicines for constipation, Phenytoin, Rifampicin and medicines for thyroid disorders.
• Medicines like anti-allergic (ranitidine), clonidine, reserpine and medicines used to treat high blood pressure like atenolol can alter the way this medicine works and may block your body’s response to low blood sugar. This can lead to dangerously low levels of blood sugar.
• Medicines like Diclofenac, Ibuprofen, Water pill, Enalapril may affect your kidney functions if taken along with this medicine.
• Medicines used to treat thyroid can affect the way this medicine works.

  Frequently Asked Questions (FAQs)

  What kind of diet should I follow?

  • A diet high in fibre and low in fats with adequate protein, carbohydrates, vitamins and minerals.
  • Maintain the regular meal timings and try to have soups and salads.
  • The diet should include boiled, steamed or baked food.
  • Ensure moderate use of edible oils (groundnut oil, olive oil) and very little use of ghee and butter.
  • Drink at least 8-10 glasses of water daily.
  • Carry fruit or low-calorie and high fibre biscuits while travelling.

  What should I avoid being a diabetic patient?

  • Do not shop when you are hungry. You could be tempted to buy oily and fried food.
  • Avoid overeating.
  • Avoid maida, white bread, potato, noodles, cornflakes, poori, biryani, naan, fried rice, etc.
  • Stop having daals with ghee and deep-fried pulses.
  • Avoid cream soups, carrot juice, deep-fried vegetables and vegetable curries with excess oil.

  I have experienced abdominal pain with loss of appetite since a few days ago, is it a side effect of Zoryl M2 forte?

  Zoryl M2 forte may have undesirable effects on your liver, especially when you are taking it for a long period of time. Thus, abdominal pain and loss of appetite may indicate the possibility of jaundice. It is recommended that if you experience these symptoms persistently, kindly visit your doctor and get expert advice about the causative factor of the same.

  My blood sugar falls too often, what could be the reason?

  • Avoid skipping meals, fasting, too much alcohol intake, taking alcohol on an empty stomach and taking a double dose.
  • If you are taking any medicines mentioned in the drug interaction section, you need to inform your doctor.
  • Always keep a juice or sugar candy with you. In case you experience symptoms of hypoglycaemia like headache, irritability, drowsiness, reduced alertness or nausea, immediately have the juice or glucose.
  • Do not have artificial sweeteners in this situation.
  • If such episodes happen too often, inform your doctor, as you may need a decrease in the dose of this medicine.

  How does Zoryl M Forte Tablet work?

  • Zoryl M Forte Tablet is known to control blood sugar to a greater extent than metformin or glimepiride alone. Glimepiride lowers the blood sugar level, increasing the release of insulin hormone from the pancreas.
  • Insulin moves sugar (glucose) from the blood into the cells.
  • Metformin decreases the absorption in the intestine and the production of sugar by the liver.
  • Both of these components are known to increase the insulin sensitivity of the body (allows the cells of the body to use blood glucose more effectively, reducing blood sugar).

  When should I take Zoryl M2 forte tablet?

  Take this tablet in the correct doses and for the exact duration as recommended by your doctor. This medicine is usually taken with food to avoid episodes of low blood sugar.

  What is the composition of Zoryl M2 Forte?

  Zoryl M2 Forte composition consists of a combination of glimepiride and metformin as its active ingredient. It belongs to an anti-diabetic class of medicines.

  When should I take Zoryl M2 Forte?

  Take Zoryl M2 Forte tablet as prescribed by the doctor for the prescribed duration. Take with food, as a whole, with a glass of water. Avoid skipping meals as well as medicine.

  What are the side effects of Zoryl M2?

  Headache, nausea, vomiting, sleepiness and drop in blood sugar levels are a few common side effects that can be seen during the treatment. Although not everyone gets them. Side effects often improve as your body gets used to the medicine.

  What is Zoryl M2 forte used for?

  Zoryl M2 Forte use is to treat type 2 diabetes mellitus when diet, exercise and glimepiride or metformin alone are not able to control the blood sugar levels.

  Does Zoryl M Forte Tablet cause low blood sugar levels?

  Sometimes, it may increase the risk of drop in blood sugar level as a side effect. So try to take your meals on time while taking Zoryl M Forte Tablet. However, if you experience any symptoms related to hypoglycaemia, such as drowsiness, unconsciousness, confusion, etc., immediately drink the juice or eat the chocolate bar. Note that artificial sweeteners are not of any use in such scenarios. Always keep a juice or a bar of chocolate in the car close to you while driving or if you have frequent episodes of hypoglycaemia.